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Ultrasonic Homogenizer Published Papers

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Article No. Title
UH1051 Nigrostriatal Dysfunction in Familial Alzheimer’s Disease-Linked APPswe/PS1 E9 Transgenic Mice Sylvia
  SYLVIA E. PEREZ, ORLY LAZAROV, JAMES B. KOPRICH, ER-YUN CHEN, VIRGINIA RODRIGUEZ-MENENDEZ, JACK W. LIPTON, SANGRAM S. SISODIA, AND ELLIOTT J. MUFSON
PDF icon Alzheimer’s disease (AD) is often accompanied by extrapyramidal signs attributed to nigrostriatal dysfunction. The association between amyloid deposition and nigrostriatal degeneration is essentially unknown. We showed previously that the striatum and the substantia nigra of transgenic mice harboring familial AD (FAD)-linked APPswe/PS1 E9 mutants exhibit morphological alterations accompanied by amyloid- (A ) deposition (Perez et al., 2004). In the present study,wefurther investigated the interaction betweenA deposition and dopaminergic nigrostriatal dysfunction, by correlating morphological and biochemical changes in the nigrostriatal pathway with amyloid deposition pathology in the brains of 3- to 17-month-old APPswe/PS1 E9 transgenic mice and age-matched wild-type controls. We show thatA deposition is pronounced in the striatum of APPswe/PS1 E9 mice at 6 months of age, and the extent of deposition increases in an age-dependent manner. Tyrosine hydroxylase (TH)-positive dystrophic neurites with rosette or grape-like cluster disposition are observed adjacent to A plaques and display multilaminar, multivesicular, and dense-core bodies as well as mitochondria. In addition, an age-dependent increase ofTHprotein levels are shown in nigral cells in these mutant mice. Using HPLC analysis, we found a reduction in the dopamine metabolite DOPAC in the striatum of these mice. These findings show a close association between amyloid deposition and nigrostriatal pathology and suggest that altered FAD-linked amyloid metabolism impairs, at least in part, the function of dopaminergic neurons.
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UH1052 Field-induced motion of ferrofluids through immiscible viscous media: Testbed for restorative treatment of retinal detachment
  OLIN T. MEFFORDA, ROBERT C. WOODWARDB, JONATHAN D. GOFFA, T.P. VADALAA, TIM G. ST. PIERREB, JAMES P. DAILEYC, JUDY S. RIFFLEA
PDF icon Biocompatible, hydrophobic ferrofluids comprised of magnetite nanoparticles dispersed in polydimethylsiloxane show promise as materials for the treatment of retinal detachment. This paper focuses on the motion of hydrophobic ferrofluid droplets traveling through viscous aqueous media, whereby the movement is induced by gradients in external fields generated by small permanent magnets. A numerical method was utilized to predict the force on a spherical droplet, and then the calculated force was used to estimate the time required for the droplet to reach the permanent magnet. The calculated forces and travel times were verified experimentally. 2006 Elsevier B.V. All rights reserved.
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Ultrasonic Homogenizers
Sometimes referred to as, Sonicator, Cell Disruptor or Cell Disrupter, Probe Sonicator, Ulrasonicator, Sonifier®, Sonic Dismembrator, and Ultrasonic Liquid Processor.

Sonifier is a registered trademark of Branson Ultrasonics Corporation

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BIOLOGICS MANUFACTURES ULTRASONIC HOMOGENIZERS

Our the Ultrasonic Homogenizer product line is being expanded to include the MultiSonic and AutoSonic, both robotic systems, for multi sample processing of volumes ranging from 250 µl to 50 ml. 

Titanium Tips and Accessories were also expanded to allow processing of a wider range of sample volumes.

Ultrasonic Homogenizers are also referred to as Sonicators, Cell Disruptors, Probe Sonicators, Sonifiers®, and Sonic Dismembrators

Sonifier is a registered trademark of Branson Ultrasonics Corporation

 
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